Review
Open access
Sep 2026
Therapeutic Intervention of PBK/TOPK: Bridging Cellular Signaling to Drug Discovery.
PBK/TOPK is a serine/threonine kinase belonging to the mitogen-activated protein kinase kinase family, involved in the regulation of cell survival, proliferation, growth, apoptosis, and inflammation response. It is overexpressed in various malignant tumors and participates in chromosome condensation, mitotic progressio...
Cheng-Peng Sun, Xin-Yuan Li, Qi-Meng Zhu et al.
· Pharmacological Research · 0 citations