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Open access Aug 2026

Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.

Co-evolution between viruses and autophagy has led to the emergence of viral strategies that manipulate host endoplasmic reticulum (ER) homeostasis, ultimately promoting viral replication. ER turnover is achieved through selective autophagy, also referred to as ER-phagy, which is regulated by the RETREG1/FAM134B (retic...

Jingyu Mao, Ju Yu, Penghui Zeng et al. · 0 citations
Open access Aug 2026

Y-box-binding protein 1 stabilizes the capsid protein of porcine circovirus type 2 to promote viral replication

Porcine circovirus type 2 (PCV2), a major causative agent of PCV2-associated diseases, poses a serious threat to the global swine industry. The stability of PCV2 capsid (Cap) protein is critical for viral replication; however, the underlying mechanisms regulating Cap stability during PCV2 infection remain poorly unders...

Jianwei Zhou, Qianqian Zhang, Xue Dong et al. · 0 citations

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