Júlia Helena de Souza Santos

Rational design of a consensus bothropic metalloproteinase as an immunogen for broadly protective antivenom development.

Antivenoms remain the only specific therapy for snakebite envenoming. In Bothrops venoms, Snake Venom Metalloproteinases (SVMPs) are abundant and highly diverse toxins responsible for the major local and hemotoxic effects induced by envenoming. However, currently available bothropic antivenoms fail to fully neutralize...