Review
Open access
Aug 2026
A three-drug polysubstance use model of ethanol, nicotine, and cocaine co-use in female and male cynomolgus monkeys.
BACKGROUND Polysubstance use is common in cocaine use disorder (CUD), yet most preclinical models still study cocaine in isolation. A recent Pharmacological Reviews article (Rough and Nader, 2026) from our group identified a major preclinical gap: despite epidemiologic evidence that most people who use cocaine also co-...
Mia I. Rough, Julia L. Kratzenberg, Cameron F. Rough et al.
· Drug and Alcohol Dependence · 0 citations