Review
Open access
Oct 2026
TDP-43 and ALS - what's wrong with my membranes?
In recent years, multiple pathologies of the mRNA binding protein TDP-43 have been linked to the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS), in which almost 97% of all ALS patients exhibit TDP-43 abnormalities in affected neurons. Typically, neuronal degeneration first affects alpha motor neurons of...
Regina Dahlhaus, Israfil Yalcin, Julia Tischer et al.
· Neurobiology of Disease · 0 citations