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Author

Julia Walker

2 papers indexed here

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Open access Sep 2026

53 Nephrectomy Remodels Peripheral Myeloid Cell States in Renal Cell Carcinoma

Abstract Background Renal cell carcinoma (RCC) is a highly immunogenic cancer characterized by abundant CD8+ T cell infiltration, yet most patients do not achieve durable responses to immunotherapy. Notably, surgical removal of the primary tumor, even in metastatic disease, may enhance response to immunotherapy, an eff...

S. Schwartz, L. Wirth, Julia Walker et al. · 0 citations
Open access Oct 2026

Pharmacologic HIF-2α inhibition preserves T cell effector function in clear cell renal cell carcinoma.

Hypoxia-inducible factor 2α (HIF-2α) is a central oncogenic driver in clear cell renal cell carcinoma (ccRCC) and a therapeutic target of the small-molecule inhibitor belzutifan. Genetic studies in murine models have suggested that hypoxia signaling may support T cell effector programs, raising concern that HIF-2α inhi...

Katrine N. Madsen, S. Kashima, H. Soulati et al. · 0 citations

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