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Author

Julian F. Ehrmann

2 papers indexed here

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Open access Oct 2026

SIR2-mediated filament assembly activates the NLR-like protein Avs5 for bacterial antiviral defense.

Like mammalian nucleotide-binding and oligomerization domain receptors (NLRs), bacterial NLR-like proteins mediate antiviral defense. Avs5, a representative of a large family of short bacterial NLR-like proteins, contains an N-terminal SIR2 effector, a central nucleotide-binding domain (NBD), and a C-terminal sensor do...

Chen Wang, Jia-Le Xie, Zhang-Fei Shen et al. · 0 citations
Open access Aug 2026

Structural basis of GSDME pore formation and its regulation by S-palmitoylation

Pyroptosis is defined as gasdermin-mediated lytic programmed cell death. Gasdermin E (GSDME), a substrate of the apoptotic caspase-3, can convert apoptosis into pyroptosis, with critical roles in antitumor immunity and chemotherapy-induced tissue damage. Despite its importance, the structural mechanism of GSDME pore fo...

Gang Du, Julian F. Ehrmann, Judy Lieberman et al. · 0 citations

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