Neurodegeneration across species: analysis of the differences between canine degenerative myelopathy and human amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) and canine degenerative myelopathy (DM) are highly complex neurodegenerative diseases characterized by progressive motor impairment and associated with mutations in the SOD1 gene, sharing common genetic mechanisms. This review analyzed, from a translational perspective, recent therap...