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Author

Julie Y. Huang

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Oct 2026

The effect of sedimentation on the unbound fraction of therapeutic peptides in plasma determined using ultra-centrifugation method.

Centrifugation is a critical step in determining the unbound fraction of drug (ƒu) in plasma, as it separates unbound drug molecules from protein-bound species during plasma protein binding (PPB) assays. When applied to therapeutic peptides, however, ultracentrifugation may induce vertical concentration heterogeneity w...

Julie Y. Huang, Qin-Ying Yu, Jing Ni et al. · 0 citations
Open access Sep 2026

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

In-depth spatial profiling identifies PLA2G2D as a TDLN-centred targetable immune checkpoint for cancer immunotherapy and identifies a specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes that is associated with poor prognosis in patients.

A. van Krimpen, Julie Y. Huang, Mike Eterman et al. · 0 citations

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