Author

Julien Dilly

3 papers indexed here

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Open access Oct 2026

KRASG12C Inhibition Remodels the Non-Small Cell Lung Cancer Surfaceome to Uncover Targetable Vulnerabilities

Mutant-selective and pan-RAS(ON) multi-selective inhibitors have improved clinical outcomes for patients with RAS-driven cancers; however, adaptive resistance limits the depth and durability of response. Using an integrated genetic, transcriptomic, and mass-spectrometry-based quantitative temporal proteomic platform, w...

A. Padhye, Kalisa Kang, Fan-Yi Kong et al. · bioRxiv · 0 citations

Sep 2026

FAK inhibitor and RAF/MEK clamp avutometinib enhance KRAS G12C inhibitor efficacy in preclinical models of non-small cell lung cancer.

KRAS G12C (Gly12→Cys) inhibitors (G12Cis) have improved outcomes for patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC), but their clinical benefit is limited by the emergence of resistance mechanisms. Here, we demonstrate that combining the RAF/MEK clamp avutometinib and the focal adhesion kinase (FAK)...

S. Coma, M. Musteanu, Cristina Caffarra Malvezzi et al. · Science Translational Medici... · 0 citations

Review Sep 2026

Abstract A091: Single-cell spatial transcriptomics reveals reprograming molecular hallmarks of PanIN initiation and progression preceding histological changes

Recent studies have identified a high prevalence of low grade pancreatic intraepithelial neoplasia (PanIN) in the pancreata of healthy adults. This study aimed to characterize the transcriptomic landscape of human PanINs at single cell resolution, with the goal of identifying hallmarks of initiation and progressi...

C. Nguyen, Anders W. Ohman, Winston R. Becker et al. · Cancer Research · 0 citations