Author

Julien Mignon

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Open access Aug 2026

CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice

Summary Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response, characterized by both hyperinflammation and immunosuppression. Here, we show that the absence of the C-type lectin receptor CLEC-1—expressed particularly by lung cDC1s—improves mouse recovery following E. coli infectio...

T. Ogor, Esther Porée, J. Saenz et al. · iScience · 0 citations

Open access Aug 2026

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional d...

Harshita Sawdekar, Julien Mignon, Frank Gondelaud et al. · Protein Science · 0 citations