Open access
Jul 2026
A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia
Unconventional protein secretion mediated by gasdermin D (GSDMD) pores is essential for the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), a major driver of many inflammatory pathologies. Despite extensive investigation over the years, discovery of IL-1β secretion modulators has been hindered by...
G. Chirițoiu, S. Ghenea, Gheorghita Isvoranu et al.
· bioRxiv · 0 citations