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Author

Julius Apuy

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Jul 2026

Discovery of BBI-355, a Potent, Selective, and Orally Available Checkpoint Kinase 1 Inhibitor for the Treatment of Extrachromosomal DNA Oncogene-Amplified Cancers.

BBI-355, a potent, selective, and orally available CHK1 inhibitor, demonstrates strong antitumor activity when dosed orally in mouse xenograft models, achieving regressions both as a single agent and in combination with targeted therapies.

S. Meyer, Sudhir Chowdhry, Rachelle Elsdon et al. · 0 citations

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