Jul 2026
Optimized Chemical Modifications Enhance Lipid Nanoparticle-Mediated siRNA Silencing of YAP1 and WWTR1
Advanced sequence-modification patterns in siRNAs targeting YAP1 and WWTR1 achieved superior knockdown efficacy in vivo compared with partially modified LNP-siRNAs typically used in clinical drugs, providing a framework for chemical optimization of LNP-based siRNAs.
Kaito Ueda, Tatsuki Sato, Jumpei Sasaki et al.
· Nucleic Acid Therapeutics · 0 citations