Jun Bai

PepEDiff: Out-of-Distribution Sampling Peptide Binder Design via Protein Embedding Diffusion

PepEDiff is presented, a novel peptide binder generator that designs binding sequences given a receptor protein and the target pocket residues that outperforms state-of-the-art approaches across benchmark tests and in the TIGIT case study, demonstrating its potential as a general, structure-free framework for zero-shot peptide binder design.