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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jun-Bin He

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Sep 2026

Biosynthesis of YM-216391 Unveils a Bifunctional α-Ketoglutarate-Dependent Enzyme Catalyzes Hydroxylation and Epimerization in RiPPs

Nonheme iron/α-ketoglutarate-dependent dioxygenases (Fe/αKGDs) catalyze diverse oxidative transformations, including hydroxylation, desaturation, and ring expansion. Although these reactions are well established, Fe/αKGD-catalyzed epimerization remains rare and has not been characterized in ribosomally synthesized an...

Kai Zhang, Lian Wu, Min-Jie Yang et al. · 0 citations

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