Author

Jun-Bing Chen

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Open access Jul 2026

Cisplatin-induced ecDNA enhances tumor malignancy and accelerates chemoresistance acquire in gastric cancer.

This study revealed that cisplatin could promote ecDNA generation, which enhanced malignant phenotypes, including cell proliferation, motility and drug resistance, and was associated with poorer patient prognosis, and targeting ecDNA with inhibitors could reverse these effects.

Huanbo Zhu, Lian Chen, Long-Tao Huangfu et al. · Journal of Advanced Research · 0 citations

Jul 2026

Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization.

A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.

Yun-Fan Sun, Y. Zhong, Shang Liu et al. · Science · 0 citations