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Jun Bum Park

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Open access Aug 2026

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

The study reveals that neddylation stabilizes NFATc1, promoting osteoclastogenesis, while destabilizing Runx2, suppressing osteoblast maturation, and reveals its potential as a mechanism-driven dual-action therapeutic target for PMOP.

Joo-Yang Lee, Min Young Lee, Hong Seok Kim et al. · 0 citations

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