Golden Vesicular Nanoadjuvant-Loaded Injectable Hydrogel for Locoregional Photothermal-Immunotherapy of Unresectable Glioblastoma.
Glioblastoma (GBM) as the most malicious primary brain tumor is infiltrative and often unresectable, which coupled with a profoundly immunosuppressive tumor microenvironment (TME) lead to a poor prognosis for patients. Here, we developed a golden vesicular nanoadjuvant (Au/TLR3-V) comprising gold nanoclusters and TLR3...