Author

Jun Chen

2 papers indexed here

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Open access Aug 2026

Cascade-coupled colorimetric-fluorescent dual-signal detection of EGFR-positive extracellular vesicles via bifunctional MOF@Pt nanozyme integrated with a CHA-CRISPR system.

Extracellular vesicle (EV)-based liquid biopsy holds great promise for glioma diagnosis, but its clinical translation remains hindered by inefficient isolation of disease-relevant EV subpopulations and insufficiently integrated signal validation. Herein, we develop a platform that integrates a bifunctional nanozyme sys...

Yan Wang, Bo-Ya Xu, Zehan Zeng et al. · Biosensors & bioelectronics · 0 citations

Sep 2026

Real-Time In Situ Imaging of Immunotherapy Efficacy: A DNA Nanowire-Based Biosensor for Granzyme A-Mediated APE1 Inactivation.

Real-time monitoring of natural killer (NK) cell-mediated cancer immunotherapy efficacy at the cellular and organismal levels remains a critical challenge, primarily due to the ultra-low abundance of Granzyme A (GzmA) delivered into target cells, its rapid spatiotemporal dynamics, and the scarcity of suitable in situ i...

Zi-Yue Qiu, Lu-Yin Zhang, Ya-Ting Hou et al. · ACS Sensors · 0 citations