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The findings reveal the functional role of KDM6A in CRPC and suggest its potential utility in exploring novel therapeutic strategies for CRPC.
Resistance to androgen receptor (AR)-targeted therapies remains a major clinical challenge in advanced prostate cancer. Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance. During anti-AR therapy, cancer cells progressively lose the positive feedb...
A pH-responsive nanocomposite engineered by functionalizing brain-metastatic tumor cell-derived exosomes with RGD peptides for targeted co-delivery of verteporfin and αPD-L1 successfully remodels the intracranial immunosuppressive microenvironment and triggers potent systemic anti-tumor immunity.
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