Extracellular vesicles (EVs) are promising endogenous nanocarriers, yet how biomolecules adsorption shapes their in vivo fate remains unclear. Here, we examine how biomolecular corona formation regulates the biodistribution, cellular recognition, and clearance of extracellular vesicles. Using EVs derived from macrophag...
Xiao-Yan Fang, Tian-Chang He, Hao Fan et al.· Journal of Controlled Releas...· 0 citations
Biomolecular corona (BC) governs nanoparticle (NP) interactions with biological systems. While the role of proteins in BC regulation is well recognized, the contribution of serum lipids remains largely unexplored. Here, silica magnetic NPs were incubated with normal or hyperlipidemic serum to form BC@NPs, followed by l...
Biological and translational evidence is synthesized to examine factors that may constrain the clinical efficacy of GPC3-targeted therapies, including antigen-related features, tumor microenvironment–associated barriers, and platform-specific challenges.
Na Li, Shu-Rong Li, P. Cao et al.· Cancer Gene Therapy· 1 citation
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