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Open access Aug 2026

Development of a new recombineering system for Edwardsiella species

Edwardsiella species are important aquaculture pathogens that also cause opportunistic infections in humans, necessitating efficient genome editing tools to study their pathogenesis and develop control strategies. In this study, we identified and characterized six endogenous recombinases pairs from Edwardsiella and its...

Yun-Jia Deng, Jia-Yu Sun, Hai-Yi Ji et al. · 0 citations
Open access Aug 2026

Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy

PTEN and p53 are two pivotal tumor suppressors that synergistically restrain tumor progression but are frequently inactivated in cancer. Restoring their functions is a promising therapeutic strategy but remains limited by unsustainable protein production and off-target effects. Here, we report a biohybrid platform inte...

Shijie Bi, Mao-Qin Wang, Qing Guan et al. · 0 citations

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