Author

Jun Hua

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Open access Aug 2026

Development and validation of an explainable XGBoost model for early mortality prediction in pediatric sepsis

Objective To develop and internally validate an explainable machine learning model for early mortality prediction in pediatric sepsis using routinely available clinical variables, to support clinical risk stratification and decision-making. Methods A total of 752 children with sepsis admitted to the Pediatric Intensive...

Hong-Mei Chen, Li-Nong Wang, Yan-Bing Fu et al. · Frontiers in Pediatrics · 0 citations

Open access Jul 2026

Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.

Findings support an immunometabolic interpretation in which EBV-related immune responses and plasma metabolite remodeling may be relevant to depression vulnerability, and they prioritize candidate metabolites and pathways for future mechanistic and clinical investigation.

Yuan Zhang, Feipeng Chen, Guoying Song et al. · Translational Psychiatry · 0 citations