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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Jun Hyeong Hong

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Open access Sep 2026

Phosphatidylserine-Engineered Lipid Nanoparticles Enable Systemic mRNA Delivery to the Central Nervous System

Intravenously administered lipid nanoparticles (LNPs) predominantly accumulate in the liver, limiting mRNA delivery to extrahepatic tissues, particularly the central nervous system (CNS). Here, we report a ligand-free strategy for systemic CNS delivery using phosphatidylserine (PS, 1 mol %)-engineered LNPs, in which...

Jun Hyeong Hong, Jae Hoon Kim, Seung-Yeul Lee et al. · 0 citations

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