Z526 alleviates cancer cachexia-induced muscle and adipose inflammatory injury in vitro via suppression of macrophage ROS-associated MAPK/NF-κB activation.
Cancer cachexia is a multifactorial syndrome characterized by skeletal muscle wasting and adipose tissue atrophy. Our previous study showed that Z526 alleviated cancer cachexia-associated symptoms and reduced circulating inflammatory cytokine levels, suggesting that its effects may involve modulation of macrophage-asso...