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Jun-Jie Shen

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Open access Oct 2026

Hypoxia-inducible CEA-targeted CAR T-cell therapy for relapsed stage IV non-small cell lung cancer.

A hypoxia-inducible CAR-T-cell product targeting carcinoembryonic antigen (CEA) that restricts CAR activation to hypoxic tumor niches via oxygen-dependent expression control is developed that provides clinical proof-of-concept for hypoxia-inducible CAR design and inform the rational development of strategies leveraging...

Shuang Wei, Jia-Qi Guo, Xue-Li Bai et al. · 0 citations

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