Jun-Jie Wu

GPR65 in cancer: expression heterogeneity, invasion and metastasis, the tumor immune microenvironment, and translational implications.

GPR65, also known as TDAG8, is a proton-sensing G protein-coupled receptor that links extracellular acidosis to intracellular signaling. Because acidic stress is a prominent feature of the tumor microenvironment, GPR65 has emerged as a potential regulator of tumor progression, immune suppression, and therapeutic respon...