Author

Jun-Jie Xu

3 papers indexed here

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Open access Aug 2026

Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by epithelial barrier disruption, persistent mucosal inflammation, and progressive intestinal fibrosis, for which effective therapeutic options remain limited. Thymosin β4 (Tβ4) is a highly conserved endogenous peptide with established ro...

Taoran Zhao, En-Bo Hu, Meng-wei Wang et al. · Molecular Biomedicine · 0 citations

Review Open access 2026

Engineering intramolecular adjuvants for next-generation vaccines

Vaccines play a pivotal role in reducing the global burden of infectious diseases. Currently, vaccine development is transitioning from empirical approaches toward precision engineering. The intramolecular adjuvant strategy, which fuses adjuvants and antigens into single molecules via genetic engineering, emerges as a...

Ye-Tong Wang, Wei-Nian Liao, Zhi-Ling Zhang et al. · The Innovation Medicine · 0 citations

Open access Sep 2026

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

It is revealed that regulatory T cells within the bone marrow microenvironment actively safeguard the survival of aged HSCs via a previously uncharacterized signaling pathway, and targeted BIRC6 inhibition in HSCs using antibody-conjugated lipid nanoparticle-encapsulated antisense oligonucleotides (LNP-ASOs) significan...

Wei-Nian Liao, Fang-Ze Shao, Shao-Yan Wang et al. · Signal Transduction and Targ... · 0 citations