Palladium-Catalyzed Asymmetric Synthesis of Methylidene Cyclobutanes via Enantioselective Intramolecular Heck-Type Reactions.
Cyclobutanes as well as 2-substituted alkylidene cyclobutanes (ADCBs) are important skeletons in pharmaceuticals and versatile precursors in organic synthesis. However, enantioselective synthesis of ADCBs remains an underexplored area of research due to the high ring strain and competing side reactions. Herein, we repo...