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Author

Jun Luo

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2 papers indexed here

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Open access Sep 2026

Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis

Mammalian spermatogenesis is highly temperature-sensitive and relies critically on the protective function of Sertoli cells. Although heat stress is known to affect Sertoli cell fate, it remains unclear whether it triggers mitoxyperilysis and by what mechanism. Leptin is a multifunctional hormone that regulates energy...

Ming Guo, Jin-Yang Zhang, Shan-Shan Gu et al. · 0 citations
Sep 2026

Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling.

Mammalian spermatogenesis is highly sensitive to temperature fluctuations. Sertoli cells provide essential support for germ cell development and are vulnerable to heat stress-induced cellular damage. Heat stress, known to impair spermatogenesis and induce cellular senescence in various cells, poses a significant threat...

Ming Guo, Ya-Wen Gao, Jin-Yang Zhang et al. · 0 citations

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