The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD), influencing amyloid-β (Aβ) aggregation, clearance, and glial function. While APOE4 promotes Aβ pathology and APOE2 is protective, how these opposing alleles interact in the heterozygous APOE2/4 state remains unknown. Her...
Kai Chen, Yi-Xing Chen, Ying-Xue Ren et al.· Nature Communications· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
Alzheimer’s disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that mod...
Er-Ming Wang, Bo-Er Xie, Minghui Wang et al.· bioRxiv· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
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