Oct 2026
A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression.
Ferroptosis is implicated in multiple human diseases, but the lack of bioavailable inducers has limited its physiological study and therapeutic translation. Here, we report KY0418, a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) featuring an isourea warhead, with high plasma stability and broad tissue...
Nathchar Naowarojna, Xin Gu, Zi-Jian Pan et al.
· Cell · 0 citations