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Jun-Qi Wu

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Open access Aug 2026

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

CDH3 is defined as a biomarker and therapeutic target linking malignant epithelial plasticity to immunosuppressive niche formation and adverse clinical behavior in TETs.

Yuntao Feng, Jing-Yu Chen, Lang Xia et al. · 0 citations
Open access Jul 2026

PRRC2A-mediated m6A modification on NCOA4 promotes thymic epithelial tumor progression through PKM2-induced glycolysis

In vivo experiments showed that inhibition of PRRC2A suppressed tumor growth and metastasis in TETs, while combined treatment with the PKM2 inhibitor C599 and PRRC2A knockdown produced enhanced antitumor effects, suggesting that the PRRC2A-NCOA4-PKM2 axis represents a promising therapeutic target.

Tao Wang, Lang Xia, Lei Zhang et al. · 0 citations

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