Author

Jun-Qin Lei

2 papers indexed here

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Open access Sep 2026

Chitosan-selenium nanoparticles prevent retinal ganglion cell apoptosis in glaucoma via activation of the PI3K/Akt/Nrf2 antioxidant axis.

Glaucoma is a prominent global cause of irreversible vision loss, fundamentally driven by the continuous degeneration and ultimate death of retinal ganglion cells (RGCs), in which persistent oxidative stress plays a pivotal role. While selenium (Se) offers robust endogenous antioxidant defense, the severe toxicity and...

Yu-Jia Huo, Miao Wei, Xiao Fan et al. · Biochemical Pharmacology · 0 citations

Sep 2026

Andrographolide-loaded PLGA nanoparticles protect retinal ganglion cells against experimental acute glaucomatous injury and attenuate mitochondrial dysfunction and retinal PANoptosis-related changes.

Acute glaucomatous injury is characterized by abrupt intraocular pressure elevation, retinal ischemia/reperfusion-like stress, and rapid retinal ganglion cell (RGC) degeneration, in which oxidative stress, mitochondrial dysfunction, and regulated cell death play important roles. Emerging evidence further implicates PAN...

Xiao Fan, Ruo-Tong Ouyang, Yu-Jia Huo et al. · International journal of pha... · 0 citations