Author

Jun Song

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Open access Sep 2026

A Novel SINE Transposable Element-Associated lncRNA Regulates Zygotic Genome Activation in Porcine Parthenogenetically Activated Embryos

Zygotic genome activation (ZGA) is a pivotal event during early mammalian embryonic development and is regulated by multiple molecular factors. In mice, previous studies have demonstrated that long non-coding RNAs (lncRNAs) and transposable elements (TEs) participate in the regulation of this process. However, the func...

Tian-Yao He, Shan Zhang, Shi-Chao Zhang et al. · Cells · 0 citations

Open access Jul 2026

A Helicase-Fused Cas9 improves Large-Size Fragment Knock-in.

MCCas is established as a promising gene editing tool with enhanced ls-KI capacity and relies on the canonical HR pathway, as inhibition of key processes such as end resection and strand invasion abolished the enhancement.

Duowei Zhao, Xiangjie Zhao, Yuhang Gao et al. · Molecular Therapy · 0 citations