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Open access Oct 2026

Time-Stable Ferroptosis-Related Candidate Genes in Myocardial Ischemia/Reperfusion Injury Identified by Multi-Time-Point Transcriptomic Analysis: Prioritization of NCF2 Through Public Datasets and AC16 Cell Validation

Background Ferroptosis contributes to myocardial ischemia/reperfusion injury (MIRI), but time-stable ferroptosis-related transcriptional features across reperfusion stages and their links to peripheral immune profiles remain unclear. This study aimed to identify time-stable ferroptosis-related candidates in MIRI using...

Rong Huang, Jun Wang, Jun-Chen He et al. · 0 citations
Sep 2026

Astragaloside IV attenuates cerebral ischemia-reperfusion injury by suppressing PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress through activation of the SHH signaling pathway.

BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SH...

Ping-Bo Wei, Yang-Yun Han, Jun Wang et al. · 0 citations

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