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Jun-Xian Liu

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Open access Sep 2026

Mineralocorticoid Receptor Blockade Mitigates Loop Diuretic-Exacerbated Plasma Volume Contraction and Target-Organ Fibrosis in Angiotensin II-Induced Hypertension

Diuretics are widely used antihypertensive agents because of their potent natriuretic effects. However, in hypertension with excessive renin–angiotensin–aldosterone system (RAAS) activation, further volume depletion may aggravate target-organ injury. We investigated the effects of loop diuretics and mineralocorticoid r...

Jun-Xian Liu, Yin-Hua Zhang · 0 citations

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