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Open access Sep 2026

Integrated Multi-Omics and Experimental Evidence Implicates PDCD5 as a Candidate Gene Associated with Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disorder in which endoplasmic reticulum stress and mitochondrial dysfunction overlap with features associated with paraptosis. This study aimed to identify a paraptosis-related candidate gene for PBC via multi-omics integration and experimental valida...

Zi-Hao Xu, Yi-Fan Liu, Cong-Cong Cao et al. · 0 citations
Open access Sep 2026

Elevated cytokines in osteoporotic blood correlate with immune microenvironment shifts and dysregulated circRNA profiles

Background Osteoporosis (OP) pathogenesis is inextricably linked to immune microenvironment dysregulation. However, the sex-specific immunoregulatory disparities between senile osteoporosis (SOP) and postmenopausal osteoporosis (PMOP) remain incompletely elucidated. Methods In this study, we integrated multi-cohort bul...

Ying Wang, Ying-Qing Chen, Ali Deng et al. · 0 citations

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