Sep 2026
TET1-mediated demethylation of UGT1A1 suppresses neuronal ferroptosis and brain injury in bilirubin encephalopathy.
BACKGROUND Bilirubin encephalopathy (BE) is a severe neurological complication of neonatal hyperbilirubinemia, but the molecular mechanisms underlying bilirubin-induced brain injury remain unclear. We investigated whether UDP-glucuronosyltransferase 1A1 (UGT1A1) regulates neuronal ferroptosis in BE and whether this pro...
Xiao-Ling Yang, Qingmingai Duan, Bei-Bei Lei et al.
· Tissue & Cell · 0 citations