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Author

Jun Yang

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Sep 2026

Decoding the Biological Function of Bile Acids for Drug Discovery

This Account identified the G-protein-coupled receptor MRGPRX4 (hX4) as a human bile acid receptor mediating cholestatic pruritus and demonstrated that sulfated bile acids are key endogenous pruritogens that accumulate in patients with cholestasis.

Jun Yang, Xiao-Guang Lei · 0 citations

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