UBA1 enhances phagocytosis by suppressing CD47 expression in small cell lung cancer
Introduction Small cell lung cancer (SCLC) exhibits a limited overall response rate to immunotherapy, largely due to its highly immunosuppressive microenvironment. CD47, an innate immune checkpoint frequently overexpressed on SCLC cells, contributes to immune evasion by inhibiting macrophage-mediated phagocytosis. Here...