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Author

Junyao Zhang

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Open access Aug 2026

TFEB Deficiency Impairs Male Fertility Through Mitochondrial Dysfunction.

Transcription Factor EB (TFEB) is widely recognized as a key transcription factor regulating lysosomal biogenesis and autophagy. Although the TFEB gene is highly expressed in the testes, the mechanism by which it affects male fertility remains unclear. Here, we report that spermatogonia-specific deletion of TFEB in mic...

Hong-Xia Li, Guo-Qing Zhao, Ruo-Jun Zong et al. · 0 citations
Jul 2026

Lactate-associated H3K18 lactylation is involved in IGF2BP2-mediated MARCKSL1 mRNA stabilization and inflammatory signaling in LPS-induced acute lung injury.

N6-methyladenosine (m6A) RNA modification regulates pulmonary inflammation, yet the precise function of the m6A reader IGF2BP2 in acute lung injury (ALI) remains elusive. Here, we reveal that IGF2BP2 and global m6A levels are significantly upregulated in lipopolysaccharide (LPS)-induced ALI. Prophylactic genetic silenc...

Yangdi Peng, Junyao Zhang, Yang Yang et al. · 0 citations

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