Author

Junfei Weng

2 papers indexed here

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Aug 2026

STK39 interacts with MAPK14 to facilitate cardiomyocyte pyroptosis in septic cardiomyopathy by inducing NLRP3 inflammasome.

BACKGROUND Septic cardiomyopathy (SCM) is a severe manifestation of sepsis characterized by myocardial dysfunction and systemic inflammation. The NLRP3 inflammasome-driven pyroptosis plays a pivotal role in SCM pathogenesis. This study aimed to elucidate the upstream molecular regulators of pyroptosis in SCM and invest...

Wei Dong, Wen Liu, Yan Yin et al. · Molecular Immunology · 0 citations

Jul 2026

Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy

METTL1 aggravated myocardial injury by inhibiting PINK1/Parkin-mediated mitophagy through the upregulation of USF2 in a m7G-dependent manner in SCM models, thereby identifying METTL1 as a potential therapeutic target for SCM.

Wei Dong, Jin Chen, Zhiping Xiong et al. · Cardiovascular Toxicology · 0 citations