Sep 2026
CD44 Receptor-Guided Hyaluronic Acid Nanogels with Dual-Stimuli Responsiveness and Lysosomal Disruption Capability for In Vivo Protein Delivery in Lung Cancer Treatment
Protein delivery nanosystems must balance stable loading, barrier navigation, and targeted, controlled release. Herein, a pH/ROS dual-responsive nanogel (PRNG) was constructed by forming dynamic boronic ester crosslinkers between PEGylated hyaluronic acid bearing diethylenetriamine-grafted-catechol groups (PEG-HA-Die...
Wei Jiang, Wei Sun, Si-Qi Zhan et al.
· Biomacromolecules · 0 citations