Author

Jung-Hwa Ryu

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Open access Sep 2026

Uremic toxin-induced pathological signaling in sinus node cells is attenuated by probenecid.

INTRODUCTION Uremic toxins, including indoxyl sulfate (IS) and p-cresyl sulfate (PCS), contribue to cardiac fibrosis and maladaptive remodeling in chronic kidney disease (CKD). Although their roles in ventricular and vascular pathology are well established, their effects on sinus node cells and the associated molecular...

Dal-Ah Kim, Chor Ho Jo, Mi-Ran Lee et al. · CardioRenal Medicine · 0 citations

Open access Aug 2026

Association Between Systolic Blood Pressure Time in Target Range and Graft Outcomes in Kidney Transplant Recipients: Result From KOTRY and KNOW-KT.

BACKGROUND Time in target range (TTR) for blood pressure reflects the consistency of blood pressure control and may better predict outcomes than single measurements. We examined the association between systolic blood pressure (SBP)-TTR and graft outcomes in kidney transplant recipients. METHODS We conducted a prospec...

Hee Byung Koh, Hyo Jeong Kim, C. Park et al. · Journal of the American Hear... · 0 citations

Open access Sep 2026

Vitamin D alleviates indoxyl sulfate-induced inflammatory and cholesterol dysregulation in macrophages: Implications for vascular health in patients receiving hemodialysis

Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with chronic kidney disease (CKD) and promotes oxidative stress, endothelial dysfunction, vascular smooth muscle cell proliferation, and fibrosis, thereby contributing to vascular stenosis in patients receiving hemodialysis. CKD is also c...

Kyoung-Hye Kong, Kyung-Sook Yang, Jung-Hwa Ryu · PLoS ONE · 0 citations