Jungil Hong

Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function

Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target for cancer. Although lapatinib has been reported to induce ferroptosis in several cancer types, we found that it exerts a ferroptosis-suppressive effect under cysteine deprivation. Lapatinib a...