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Author

Junlin Yang

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Jul 2026

Frontis-MA1: Training an AI4AI Model towards Recursive Self-Improvement in Machine Learning Engineering

Recursive self-improvement (RSI) requires AI systems that improve the process of building AI (i.e., AI4AI); machine learning engineering (MLE) offers a concrete, executable testbed for studying this capability. We introduce OpenMLE, an open full-stack system for RSI research in MLE, spanning verifiable task environments with execution feedback (OpenMLE-Gym), operator learning (OpenMLE-RL), and long-horizon search (OpenMLE-Evo). On this stack we post-train Frontis-MA1 (35B) as a meta-evolution agent for MLE, aligning post-training and inference around four atomic program-evolution operators (Draft, Improve, Debug, Crossover): the same operators are trained via execution-grounded SFT and RL on data deduplicated against all evaluation benchmarks, then composed into long-horizon search, coupling learning and evolution in a single loop. On MLE-Bench Lite under a 12-hour per-task budget on one RTX 4090 capped at 12 GB VRAM, Frontis-MA1 (35B) improves Medal Average from 39.39% to 60.61% over its base model with OpenMLE-Evo, and reaches 71.21% with OpenMLE-Evo-Max (benchmark-independent experience priors and asynchronous search), exceeding GPT-5.5 + Codex and approaching GPT-5.6 Sol and the 2.8T Kimi K3. On held-out NatureBench Lite, both components transfer: with the framework fixed, swapping in the trained model raises Match-SOTA from 50% to 70%; with the model fixed, swapping in OpenMLE-Evo raises it from 20% to 50%. We release the model weights and the full OpenMLE stack to enable reproducible research on executable AI4AI toward RSI. Code: https://github.com/FrontisAI/OpenRSI

Junlin Yang, Che Jiang, Yu Fu et al. · 3 citations
Jul 2026

Dual Selective Pressure and Intelligent Screening of Mutagenized Bacillus subtilis for Enhanced Riboflavin Production.

Riboflavin is an essential nutrient widely used in food, feed, and pharmaceutical industries, yet efficient screening of high-yield microbial strains remains a major bottleneck in industrial production. Here, we developed an integrated strategy combining dual selective pressure, optimized microplate fermentation, and stepwise high-throughput screening to accelerate the isolation of riboflavin-overproducing Bacillus subtilis mutants. A dual selective pressure system employing phosphonoarginine-5-amino-6-(d-ribosylamino)uracil (Arp) and the GTP analog 8-azaguanine (8-AZG) enhanced the positive mutation rate. Optimization of microplate culture enabled strong correlation across 96-well, 24-well, and shake-flask fermentations. Stepwise screening further enriched stable high producers, achieving a final positive rate of 21.4%. The best mutant, Hs-G87, produced 4.1 g/L riboflavin in shake flasks and 32.1 g/L in a 5 L bioreactor (yield of 0.11 g/g glucose; productivity of 0.594 g/L/h), demonstrating strong industrial potential.

Fangyu Zhang, Guangqing Du, Miaomiao Xia et al. · 0 citations

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