Author

Junwei Sun

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Open access Jul 2026

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

This work systematically evaluates a diverse set of deep learning and non-deep-learning methods for their ability to predict differential expression outcomes under two generalization regimes: unseen perturbations within the same cell line, and unseen cellular contexts across cell lines.

Junwei Sun, Yuxun He, Ouyang Zhu et al. · bioRxiv · 0 citations