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Apoptotic macrophage-derived vesicles serve as an effective platform for oncolytic adenovirus delivery, improving anti-tumor efficacy in vitro and exhibiting significantly enhanced cytotoxicity against tumor cells.
The results support IND-enabling studies of ADT-030 as a monotherapy or in combination with standard-of-care treatments for patients with a broad range of RAS-driven cancers, and especially for patients who relapsed after RAS inhibitor treatment.
An orally bioavailable prodrug of ADT-1004, ADT-1004, demonstrated favorable tolerability and suppressed tumor growth in orthotopic and patient-derived xenograft models of pancreatic cancer, accompanied by reductions in activated RAS and p-ERK levels (Mol Cancer, 2025).
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